Posted by: Indonesian Children | November 26, 2009

Food Intake of Children with Short Stature Born Small for Gestational Age before

Food Intake of Children with Short Stature Born Small for Gestational Age before and during a Randomized GH Trial

V.H. Boonstraa, N.J.T. Arendsa, T. Stijnenb, W.F. Blumc, O. Akkermana, A.C.S. Hokken-Koelegaa

aDivision of Endocrinology, Department of Pediatrics, Sophia Children’s Hospital/Erasmus University, and
bInstitute of Epidemiology and Biostatistics, Erasmus University, Rotterdam, The Netherlands;
cLilly Research Laboratories, University Children’s Hospital, Giessen, Germany

  Abstract

Parents of short children born SGA often report that their children have a serious lack of appetite and a low food intake. In this study we investigated food intake, by using a standardized 7-day food questionnaire, in 88 short SGA children before start of GH treatment. The intake was compared with the recommended daily intake (RDI) of age-matched children. We also compared the food intake of GH-treated children (n = 62) with randomized controls (n = 26) after 1 year of GH treatment. In addition, we evaluated the effect of food intake and GH treatment on body composition and serum levels of IGF-I, IGFBP-3 and leptin. Our study shows that caloric intake, fat and carbohydrate intake of short SGA children aged 5.9 (1.6) years was significantly lower compared to the RDI for age-matched children. One year of GH treatment resulted in a significant increase of caloric, fat, carbohydrate and protein intake compared to baseline. Compared to randomized controls, caloric, carbohydrate and protein intake increased significantly after 1 year of GH treatment. Short SGA children had significantly lower SDS scores for LBM, fat mass, skinfold (SF) and BMI compared to age-matched references. They also had significantly lower serum IGF-I, IGFBP-3 and leptin levels. GH treatment resulted in a significant increase of height, LBM, BMI, IGF-I and IGFBP-3 SDS and a significant decrease of SF SDS and leptin SDS. In conclusion, our study shows that short SGA children have indeed a lower food intake than age-matched controls. During GH treatment the food intake increased significantly compared to baseline in contrast to the randomized control group.

Copyright © 2006 S. Karger AG, Basel

  Author Contacts

Dr. V.H. Boonstra
Sophia Children’s Hospital
Division of Endocrinology, Department of Pediatrics
Dr. Molewaterplein 60, NL-3015 GJ Rotterdam (The Netherlands)
Tel. +31 10 463 6643, Fax +31 10 463 6811, E-Mail venje@tevreden.nl

  Article Information

Part of this study was presented at the 39th Annual Meeting of the European Society for Paediatric Endocrinology, Brussels, September 2000.


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