Posted by: Indonesian Children | December 6, 2009

Efficacy of oral erythromycin for treatment of feeding intolerance in preterm infants

Volume 148, Issue 5, Pages 600-605 (May 2006)
 
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KLINIK KHUSUS KESULITAN MAKAN PADA ANAK

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email : judarwanto@gmail.com,

 

 

                                                                                                            

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Copyright © 2009, Picky Eaters Clinic Information Education Network. All rights reserved.

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Efficacy of oral erythromycin for treatment of feeding intolerance in preterm infants

Pracha Nuntnarumit, MD, MScabcdCorresponding Author Informationemail address, Pakaphan Kiatchoosakun, MDabcd, Wacharee Tantiprapa, MDabcd, Suppawat Boonkasidecha, MDabcd

Received 18 June 2005; received in revised form 3 November 2005; accepted 7 December 2005.

Objective

To determine the efficacy and safety of oral erythromycin (EM) for feeding intolerance in preterm infants < 35 weeks gestation.

Study design

In this randomized, double-blinded, placebo-controlled trial, preterm infants with feeding intolerance were randomly allocated to a treatment group given EM ethyl succinate 10 mg/kg every 6 hours for 2 days, followed by 4 mg/kg every 6 hours for another 5 days, or to a control group given placebo. The primary outcome was time to full feeding (150 mL/kg/day) after the start of treatment.

Results

Each group comprised 23 preterm infants, almost all of whom were < 32 weeks gestation. Baseline characteristics were similar between the 2 groups. Times to full feeding were significantly shorter and the number of withheld feeds were significantly less in the EM group than the control group; the respective medians (interquartile ranges) were 7 days (6 to 9 days) versus 13 days (9 to 15 days) (P < .001) and 1 episode (0 to 2 episodes) versus 9 episodes (2 to 13 episodes) (P < .001). No significant differences in episodes of sepsis, necrotizing enterocolitis, and cholestasis were observed.

Conclusions

Oral EM was effective and safe for treatment of feeding intolerance in preterm infants.

Abbreviations:  EM, Erythromycin , MMC, Migratory motor complex , NEC, Necrotizing enterocolitis , PDA, Patent ductus arteriosus

Supported by

PICKY EATERS CLINIC 

KLINIK KHUSUS KESULITAN MAKAN PADA ANAK

JL TAMAN BENDUNGAN ASAHAN 5 JAKARTA PUSAT, JAKARTA INDONESIA 10210

PHONE :62 (021) 70081995 – 5703646

Email : judarwanto@gmail.com 

https://mypickyeaters.wordpress.com/ 

 

Clinical and Editor in Chief :

Dr Widodo Judarwanto, pediatrician

email : judarwanto@gmail.com,

 

 

                                                                                                            

Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.

 

 

Copyright © 2009, Picky Eaters Clinic Information Education Network. All rights reserved.


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